Identification of molecular mechanisms leading to activation of pathogenic Th1/17 cells by pathobionts and gut microbiota in Crohn’s disease: a new target for therapeutic strategies.



24 months


€ 249.363


€ 249.363

Project mission

The project’s aim consists in a detailed study of a specific range of cells, the so called Th1/17 cells, whose massive production is related to organism’s response in patients affected by Chron’s disease. In fact, this reaction is part of a wider series of consequences generated by that chronic gastrointestinal disorder which causes an exaggerated adaptive immune answer in the gut microbiota. In genetically predisposed subjects, the cells analysed in this context induces a pro-inflammatory response to specific bacteria, such as Escherichia coli. The main goal od the project is thus to study the activation of Th1/17 cells in relation to the presence of that kind of bacteria in the gut microbiota. 

Communications materials

Belove the line

Project Partners

Consiglio Nazionale delle Ricerche
Università degli Studi di Milano

Registered office
Piazza della Trivulziana, 4/A
20126 Milan (IT)
Piazza della Trivulziana, 4/A
20126 Milan (IT)